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ZO Peptide Facial Refining Concentrate 30ml
ZO Peptide Facial Refining Concentrate – now available in clinic
Product Overview
Peptide Facial Refining Concentrate is ZO Skin Health’s advanced anti-ageing serum launched in September 2025, designed to complement the effects of neurotoxins and dermal fillers while also functioning as a powerful standalone treatment. This concentrated formula targets multiple signs of ageing through four cutting-edge peptide technologies, clinically proven to deliver a more sculpted appearance and refined facial geometry in just 12 weeks.
Key Benefits
Targets Wrinkles and Volume Loss: The formula addresses both visible expression lines (dynamic wrinkles) and static wrinkles whilst restoring the appearance of lost volume, creating a visibly lifted and more refined appearance.
Complements Injectable Treatments: Designed to work with neurotoxins (like Botox) and dermal fillers, helping patients maintain results between clinic visits whilst delivering visible improvements on its own.
Supports Skin Structure: The Refining Peptide Complex improves the appearance of skin’s structural integrity, promoting more sculpted facial geometry. The Volumizing Tripeptide supports the skin’s natural production of hyaluronic acid for a plumper, fuller look.
Reduces Visible Redness: The exclusive ZPOLY™ helps to alleviate visible redness and fortify the skin’s protective barrier.
Clinical Results
In a 12-week independent clinical study involving 49 participants aged with Fitzpatrick skin types I-VI:
92% saw a reduction in the appearance of fine lines
84% reported visibly younger-looking facial geometry (a more sculpted, balanced face overall)
86% saw improvement in facial hollow areas (places that had lost fullness)
82% experienced reduced forehead wrinkles
96% said their skin felt smoother
Additional measurements showed:
10% reduction in wrinkle volume after 4 weeks
11% improvement in visible skin texture after 12 weeks
8% improvement in skin firmness and elasticity after 2 weeks
12% in elasticity by week 12
100% of subjects showed improvement in skin hydration by week 4
Advanced Peptide Technologies
The formula is powered by four cutting-edge peptide technologies:
1. Acetyl Octapeptide-3
8 amino acids
Targets the appearance of dynamic lines and wrinkles, especially around the forehead and eye area
Functions as a neuropeptide to modulate wrinkle formation
2. Acetyl Hexapeptide-8
Contains 6 amino acids
Works synergistically with Acetyl Octapeptide-3
Provides greater precision in smoothing the appearance of deeper dynamic and static wrinkles
3. Refining Complex
Blend of 2 active peptides: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate
Supports a visibly more refined facial geometry
Improves the appearance of skin’s structural integrity
4. Volumizing Tripeptide (Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate)
A unique tri-peptide
Supports the skin’s natural production of hyaluronic acid for fuller, plumper-looking skin
Helps restore the appearance of lost volume
ZPOLY™ Complex
This ZO-exclusive, plant-derived polysaccharide complex is a blend of four polysaccharide extracts:
Laminaria digitata (brown seaweed) extract
Opuntia ficus-indica (prickly pear) stem cell extract
Schizophyllan (mushroom)
Galactoarabinan (larch tree)
Benefits: Helps prevent signs of ageing, supports skin barrier restoration, boosts extended hydration after a single application, and minimises the visible appearance of and blotchiness for a calm skin tone.
Full Ingredient List
Aqua/Water/Eau, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Fragrance (Parfum), Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Vegetable Protein, Sodium Chloride, Gum, Phenoxyethanol.
Formulation Properties
Alcohol-free and fragrance-free (though some sources list “Fragrance (Parfum)” in the full ingredient list)
Silicone-based serum with a lightweight, smooth texture
Suitable for all skin types
Makes it a perfect complement to procedures
How to Use
Application: Apply 1-2 pumps to clean, dry skin
Frequency: Morning and/or evening.
Routine Placement: Apply before moisturiser for maximum results. As a serum, it should be applied after cleansing and toning but before heavier creams or SPF
Product Pairing: Can be complemented with Firming Serum and AOX Serum for enhanced anti-ageing results
Ideal Candidates
This serum is particularly beneficial for those who:
Are experiencing both dynamic lines (from facial movement) and static lines (wrinkles when the face is relaxed)
Have signs of lost volume (around cheeks, under the eyes, or facial hollows) and want plumping effects without immediately to fillers
Would like to maintain or prolong results from treatments like fillers or Botox
Want to improve skin texture, firmness, and contour over time
Are seeking a high-performance anti-ageing solution with clinical backing
Before and afters
Results may vary from person to person, based on different personalised Skin plans.
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